POEMS Syndrome

**Definition:** A multisystemic disorder characterized by a sensorimotor polyneuropathy (POLYNEUROPATHIES), organomegaly, endocrinopathy, monoclonal gammopathy, and pigmentary skin changes. Other clinical features which may be present include EDEMA; CACHEXIA; microangiopathic glomerulopathy; pulmonary hypertension (HYPERTENSION, PULMONARY); cutaneous necrosis; THROMBOCYTOSIS; and POLYCYTHEMIA. This disorder is frequently associated with osteosclerotic myeloma. (From Adams et al., Principles of Neurology, 6th ed, p1335; Rev Med Interne 1997;18(7):553-62)

**Tree numbers:** - C10.668.829.800.700 - C15.378.147.780.750 - C16.131.077.703 - C20.683.780.750

**Synonyms:** - Crow-Fukase Syndrome - Takatsuki's Syndrome - Polyneuropathy, Organomegaly, Endocrinopathy, M Protein, and Skin Changes Syndrome - Polyneuropathy Organomegaly