CD3 Complex

**Definition:** Complex of at least five membrane-bound polypeptides in mature T-lymphocytes that are non-covalently associated with one another and with the T-cell receptor (RECEPTORS, ANTIGEN, T-CELL). The CD3 complex includes the gamma, delta, epsilon, zeta, and eta chains (subunits). When antigen binds to the T-cell receptor, the CD3 complex transduces the activating signals to the cytoplasm of the T-cell. The CD3 gamma and delta chains (subunits) are separate from and not related to the gamma/delta chains of the T-cell receptor (RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA).

**Tree numbers:** - D23.050.301.264.894.095 - D23.101.100.894.095

**Synonyms:** - T3 Antigen - T3 Antigens - CD3 Antigen - CD3 Antigens - Antigens, CD3 - T3 Complex