Receptors, Somatomedin

**Definition:** Cell surface receptors that bind somatomedins and trigger intracellular changes which influence the behavior of cells. Studies have disclosed two types of receptors for this family of peptide hormones. The type I receptor is homologous to the insulin receptor and has tyrosine kinase activity. The type II receptor is identical to the mannose-6-phosphate receptor which is important in trafficking of lysosomal enzymes.

**Tree numbers:** - D12.776.543.750.750.400.780

**Synonyms:** - Insulin-Like Growth Factor Receptor - Insulin-Like Growth Factor Receptors - Receptors, Insulin-Like Growth Factors - Somatomedin Receptor - Somatomedin Receptors