Leukocyte Common Antigens

**Definition:** High-molecular weight glycoproteins uniquely expressed on the surface of LEUKOCYTES and their hemopoietic progenitors. They contain two FIBRONECTIN TYPE III DOMAINS and possess cytoplasmic protein tyrosine phosphatase activity, which plays a role in intracellular signaling from the CELL SURFACE RECEPTORS. Leukocyte common antigens occur as multiple isoforms that result from alternative mRNA splicing and differential usage of three exons.

**Tree numbers:** - D08.811.277.352.650.775.400.100.500 - D12.776.476.564.400.100.500 - D12.776.543.733.937.500

**Synonyms:** - CD45 Antigen - CD45 Antigens - Antigens, CD45 - Protein Tyrosine Phosphatase, Receptor Type, C - L-CA Antigens - Leukocyte Common Antigen - T200 Antigens