Receptor, IGF Type 1

**Definition:** A protein-tyrosine kinase receptor that is closely related in structure to the INSULIN RECEPTOR. Although commonly referred to as the IGF-I receptor, it binds both IGF-I and IGF-II with high affinity. It is comprised of a tetramer of two alpha and two beta subunits which are derived from cleavage of a single precursor protein. The beta subunit contains an intrinsic tyrosine kinase domain.

**Tree numbers:** - D08.811.913.696.620.682.725.400.185 - D12.776.476.568.400.185 - D12.776.543.750.630.468 - D12.776.543.750.750.400.780.400

**Synonyms:** - IGF-I Receptor - Receptor, Insulin-Like Growth Factor Type 1 - Receptor, IGF-I - Receptor, Insulin-Like Growth Factor I - IGF Type 1 Receptor - Insulin-Like-Growth Factor I Receptor - Receptors, IGF-1 - IGF-1 Receptor - Receptors, Insulin-Like-Growth Factor I