B7-1 Antigen

**Definition:** A costimulatory ligand membrane glycoprotein that contains a V2 type and C2 IMMUNOGLOBULIN DOMAIN and is expressed by ANTIGEN-PRESENTING CELLS. It binds to CTLA-4 ANTIGEN with high specificity and to CD28 ANTIGEN with low specificity. The interaction of CD80 with CD28 ANTIGEN provides a costimulatory signal to T-LYMPHOCYTES, while its interaction with CTLA-4 ANTIGEN may play a role in inducing PERIPHERAL TOLERANCE.

**Tree numbers:** - D12.776.467.150.100 - D12.776.543.095.100 - D23.050.301.285.100 - D23.529.168.100

**Synonyms:** - Antigen, B7-1 - B7-1 Ligand - B-Cell Activation Antigen - CD80 Antigen - CD80 Antigens - Antigens, CD80 - B7-1 Costimulatory Molecule