Patch-Clamp Techniques

**Definition:** An electrophysiologic technique for studying cells, cell membranes, and occasionally isolated organelles. All patch-clamp methods rely on a very high-resistance seal between a micropipette and a membrane; the seal is usually attained by gentle suction. The four most common variants include on-cell patch, inside-out patch, outside-out patch, and whole-cell clamp. Patch-clamp methods are commonly used to voltage clamp, that is control the voltage across the membrane and measure current flow, but current-clamp methods, in which the current is controlled and the voltage is measured, are also used.

**Tree numbers:** - E05.200.500.905 - E05.242.800

**Synonyms:** - Patch-Clamp Technics - Patch Clamp Technique - Patch-Clamp Technique - Patch-Clamp Technic