Erb-b2 Receptor Tyrosine Kinases

**Definition:** Cell surface receptor protein-tyrosine kinases receptor that is overexpressed in a variety of ADENOCARCINOMAS. It has extensive homology to and heterodimerizes with the EGF RECEPTOR, the ERBB-3 RECEPTOR, and the ERBB-4 RECEPTOR. Activation of the erbB-2 receptor occurs through heterodimer formation with a ligand-bound erbB receptor family member.

**Tree numbers:** - D08.811.913.696.620.682.725.400.009.400 - D12.776.476.568.400.009.400 - D12.776.543.750.630.009.400 - D12.776.543.750.750.400.074.400 - D12.776.624.664.700.642 - D23.050.301.500.600.700 - D23.050.705.552.600.550 - D23.101.140.642

**Synonyms:** - Antigens, CD340 - c-erbB-2 Protein - CD340 Antigen - erbB-2 Proto-Oncogene Protein - ERBB2 Receptor Tyrosine-protein Kinase - HER-2 Proto-Oncogene Protein - Metastatic Lymph Node Gene 19 Protein - neu Proto-Oncogene Protein - Neu Receptor - Oncogene Protein HER-2 - p185(c-neu) - p185erbB2 Protein - Proto-Oncogene Protein HER-2 - Proto-oncogene Protein Neu - Proto-Oncogene Protein p185(neu) - Proto-Oncogene Proteins c-erbB-2 - Receptor tyrosine-protein kinase erbB-2 - Receptor, ErbB-2 - Receptor, Neu - Receptors, erbB-2 - Tyrosine Kinase-type Cell Surface Receptor HER2