Genes, erbB-2

**Definition:** The erbB-2 gene is a proto-oncogene that codes for the erbB-2 receptor (ERB-B2 RECEPTOR TYROSINE KINASES), a protein with structural features similar to the epidermal growth factor receptor. Its name originates from the viral oncogene homolog (v-erbB) which is a truncated form of the chicken erbB gene found in the avian erythroblastosis virus. Overexpression and amplification of the gene is associated with a significant number of adenocarcinomas. The human c-erbB-2 gene is located at 17q21.2.

**Tree numbers:** - G05.360.340.024.340.375.500.791.295.305

**Synonyms:** - c-erbB-2 Genes - c-erbB-2 Proto-Oncogenes - erbB-2 Genes - Genes, erbb2 - Genes, HER-2 - Genes, HER2 - Genes, neu