Oncogene Proteins v-erbA

**Definition:** Transforming proteins encoded by erbA oncogenes from the avian erythroblastosis virus. They are truncated versions of c-erbA, the thyroid hormone receptor (RECEPTORS, THYROID HORMONE) that have retained both the DNA-binding and hormone-binding domains. Mutations in the hormone-binding domains abolish the transcriptional activation function. v-erbA acts as a dominant repressor of c-erbA, inducing transformation by disinhibiting proliferation.

**Tree numbers:** - D12.776.624.664.520.750.882 - D12.776.964.700.750.882 - D12.776.964.775.750.882

**Synonyms:** - erbA Oncogene Proteins - Oncogene Products v-erbA - v-erbA Proteins