Proliferating Cell Nuclear Antigen

**Definition:** Nuclear antigen with a role in DNA synthesis, DNA repair, and cell cycle progression. PCNA is required for the coordinated synthesis of both leading and lagging strands at the replication fork during DNA replication. PCNA expression correlates with the proliferation activity of several malignant and non-malignant cell types.

**Tree numbers:** - D12.776.660.740 - D23.050.290.750 - D23.101.140.600

**Synonyms:** - Antigen, Proliferating Cell Nuclear - PCNA