Multiple Endocrine Neoplasia Type 2b

**Definition:** Similar to MEN2A, it is also caused by mutations of the MEN2 gene, also known as the RET proto-oncogene. Its clinical symptoms include medullary carcinoma (CARCINOMA, MEDULLARY) of THYROID GLAND and PHEOCHROMOCYTOMA of ADRENAL MEDULLA (50%). Unlike MEN2a, MEN2b does not involve PARATHYROID NEOPLASMS. It can be distinguished from MEN2A by its neural abnormalities such as mucosal NEUROMAS on EYELIDS; LIP; and TONGUE, and ganglioneuromatosis of GASTROINTESTINAL TRACT leading to MEGACOLON. It is an autosomal dominant inherited disease.

**Tree numbers:** - C04.588.322.400.510 - C04.651.600.510 - C04.700.630.510 - C16.320.700.630.510 - C19.344.400.510

**Synonyms:** - Multiple Endocrine Neoplasia, Type 2b - Multiple Endocrine Neoplasms Type 2b - Neoplasia, Multiple Endocrine Type 2b - Neoplasms, Multiple Endocrine Type 2b - Neuromata, Mucosal, With Endocrine Tumors - Wagenmann-Froboese Syndrome - Multiple Endocrine Neoplasia, Type IIb - MEN IIb - MEN III - MEN2b - MEA 2b - MEA IIb - MEN 2b - Mucosal Neuroma Syndrome - MEN 3