Proto-Oncogene Proteins c-kit

**Definition:** A protein-tyrosine kinase receptor that is specific for STEM CELL FACTOR. This interaction is crucial for the development of hematopoietic, gonadal, and pigment stem cells. Genetic mutations that disrupt the expression of PROTO-ONCOGENE PROTEINS C-KIT are associated with PIEBALDISM, while overexpression or constitutive activation of the c-kit protein-tyrosine kinase is associated with tumorigenesis.

**Tree numbers:** - D08.811.913.696.620.682.725.400.050 - D12.776.476.568.400.050 - D12.776.543.750.630.124 - D12.776.543.750.705.852.150.100 - D12.776.543.750.750.400.200.170 - D12.776.624.664.700.183

**Synonyms:** - Receptor, Stem Cell Factor - Stem Cell Factor Receptor - Proto-Oncogene Protein kit - c-kit Receptor - SCF Receptor - p145 c-kit - p145(c-kit) - p145c-kit - CD117 Antigen - Antigens, CD117 - CD117 Antigens - Proto-Oncogene Protein c-kit - kit Proto-Oncogene Protein - c-kit Protein