fas Receptor

**Definition:** A tumor necrosis factor receptor subtype found in a variety of tissues and on activated LYMPHOCYTES. It has specificity for FAS LIGAND and plays a role in regulation of peripheral immune responses and APOPTOSIS. Multiple isoforms of the protein exist due to multiple ALTERNATIVE SPLICING. The activated receptor signals via a conserved death domain that associates with specific TNF RECEPTOR-ASSOCIATED FACTORS in the CYTOPLASM. Mutations in the CD95 gene are associated with cases of autoimmune lymphoproliferative syndrome.

**Tree numbers:** - D12.776.543.750.690.500 - D12.776.543.750.705.852.760.195

**Synonyms:** - fas Antigen - fas Antigens - APO-1 Antigen - CD95 Antigen - CD95 Antigens - Antigens, CD95 - Receptors, fas - fas Receptors - Tumor Necrosis Factor Receptor Superfamily, Member 6 - Fas Cell Surface Death Receptor - TNFRSF6 Receptor