Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

**Definition:** A mass spectrometric technique that is used for the analysis of large biomolecules. Analyte molecules are embedded in an excess matrix of small organic molecules that show a high resonant absorption at the laser wavelength used. The matrix absorbs the laser energy, thus inducing a soft disintegration of the sample-matrix mixture into free (gas phase) matrix and analyte molecules and molecular ions. In general, only molecular ions of the analyte molecules are produced, and almost no fragmentation occurs. This makes the method well suited for molecular weight determinations and mixture analysis.

**Tree numbers:** - E05.196.566.755

**Synonyms:** - Mass Spectrometry, Matrix-Assisted Laser Desorption-Ionization - Matrix-Assisted Laser Desorption-Ionization Mass Spectrometry - Mass Spectroscopy, Matrix-Assisted Laser Desorption-Ionization - Spectroscopy, Mass, Matrix-Assisted Laser Desorption-Ionization - MS-MALD - MALD-MS - MALDI-MS - Laser Desorption-Ionization Mass Spectrometry, Matrix-Assisted - MALDI