Platelet Glycoprotein GPIIb-IIIa Complex

**Definition:** Platelet membrane glycoprotein complex important for platelet adhesion and aggregation. It is an integrin complex containing INTEGRIN ALPHAIIB and INTEGRIN BETA3 which recognizes the arginine-glycine-aspartic acid (RGD) sequence present on several adhesive proteins. As such, it is a receptor for FIBRINOGEN; VON WILLEBRAND FACTOR; FIBRONECTIN; VITRONECTIN; and THROMBOSPONDINS. A deficiency of GPIIb-IIIa results in GLANZMANN THROMBASTHENIA.

**Tree numbers:** - D09.400.430.890.625.785 - D12.776.395.550.625.785 - D12.776.543.550.625.785 - D12.776.543.750.705.408.460.700 - D12.776.543.750.705.675.784

**Synonyms:** - Integrin alpha-IIb beta-3 - Glycoproteins IIb-IIIa - Integrin alphaIIbbeta3 - GPIIb-IIIa Receptors