Prostatic Intraepithelial Neoplasia

**Definition:** A premalignant change arising in the prostatic epithelium, regarded as the most important and most likely precursor of prostatic adenocarcinoma. The neoplasia takes the form of an intra-acinar or ductal proliferation of secretory cells with unequivocal nuclear anaplasia, which corresponds to nuclear grade 2 and 3 invasive prostate cancer.

**Tree numbers:** - C04.557.470.200.240.500

**Synonyms:** - Intraepithelial Prostatic Neoplasia - Neoplasia, Prostatic Intraepithelial - Prostatic Intraepithelial Neoplasms