Receptors, Polymeric Immunoglobulin

**Definition:** Specialized Fc receptors (RECEPTORS, FC) for polymeric immunoglobulins, which mediate transcytosis of polymeric IMMUNOGLOBULIN A and IMMUNOGLOBULIN M into external secretions. They are found on the surfaces of epithelial cells and hepatocytes. After binding to IMMUNOGLOBULIN A, the receptor-ligand complex undergoes endocytosis, transport by vesicle, and secretion into the lumen by exocytosis. Before release, the part of the receptor (SECRETORY COMPONENT) that is bound to IMMUNOGLOBULIN A is proteolytically cleaved from its transmembrane tail. (From Rosen et al., The Dictionary of Immunology, 1989)

**Tree numbers:** - D12.776.543.750.705.871.700

**Synonyms:** - Polymeric Immunoglobulin Receptor - Polymeric Immunoglobulin Receptors - Polymeric Ig Receptor - Receptor, Polymeric Ig - Poly-Ig Receptor - Polyimmunoglobulin Receptor - Receptor, Polyimmunoglobulin