Troponin I

**Definition:** A TROPONIN complex subunit that inhibits ACTOMYOSIN ATPASE activity thereby disrupting ACTIN and MYOSIN interaction. There are three troponin I subtypes: troponin I1, I2 and I3. Troponin I3 is cardiac-specific whereas troponin I1 and I2 are skeletal subtypes. Troponin I3 is a BIOMARKER for damaged or injured CARDIAC MYOCYTES and mutations in troponin I3 gene are associated with FAMILIAL HYPERTROPHIC CARDIOMYOPATHY.

**Tree numbers:** - D05.500.945.925 - D05.750.078.730.825.925 - D12.776.210.500.910.925 - D12.776.220.525.825.925

**Synonyms:** - Troponin-I