Proto-Oncogene Proteins c-bcl-2

**Definition:** Membrane proteins encoded by the BCL-2 GENES and serving as potent inhibitors of cell death by APOPTOSIS. The proteins are found on mitochondrial, microsomal, and NUCLEAR MEMBRANE sites within many cell types. Overexpression of bcl-2 proteins, due to a translocation of the gene, is associated with follicular lymphoma.

**Tree numbers:** - D12.644.360.075.718 - D12.776.476.075.718 - D12.776.624.664.700.169

**Synonyms:** - bcl-2 Proto-Oncogene Proteins - c-bcl-2 Proteins