Antibodies, Antineutrophil Cytoplasmic

**Definition:** Autoantibodies directed against cytoplasmic constituents of POLYMORPHONUCLEAR LEUKOCYTES and/or MONOCYTES. They are used as specific markers for GRANULOMATOSIS WITH POLYANGIITIS and other diseases, though their pathophysiological role is not clear. ANCA are routinely detected by indirect immunofluorescence with three different patterns: c-ANCA (cytoplasmic), p-ANCA (perinuclear), and atypical ANCA.

**Tree numbers:** - D12.776.124.486.485.114.323.190 - D12.776.124.790.651.114.323.190 - D12.776.377.715.548.114.323.190 - D23.101.050

**Synonyms:** - ANCA - Antineutrophil Cytoplasmic Antibody - Antineutrophil Cytoplasmic Antibodies - Anti-Neutrophil Cytoplasmic Antibodies - Anti-Neutrophil Cytoplasmic Antibody - Anti-Neutrophil Cytoplasmic Autoantibody - Neutrophil Cytoplasmic Autoantibody - Anti-Neutrophil Cytoplasmic Autoantibodies - Neutrophil Cytoplasmic Autoantibodies