Phosphatidylinositol 4,5-Diphosphate

**Definition:** A phosphoinositide present in all eukaryotic cells, particularly in the plasma membrane. It is the major substrate for receptor-stimulated phosphoinositidase C, with the consequent formation of inositol 1,4,5-triphosphate and diacylglycerol, and probably also for receptor-stimulated inositol phospholipid 3-kinase. (Kendrew, The Encyclopedia of Molecular Biology, 1994)

**Tree numbers:** - D10.570.755.375.760.400.942.625.900

**Synonyms:** - Phosphatidylinositol 4,5-Biphosphate - Phosphatidylinositol Phosphate, PtdIns(4,5)P2 - Phosphatidylinositol-4,5-Biphosphate - PtdIns(4,5)P2 - PtdInsP2 - PtdInsP - PtIns 4,5-P2