Endothelin-1

**Definition:** A 21-amino acid peptide produced in a variety of tissues including endothelial and vascular smooth-muscle cells, neurons and astrocytes in the central nervous system, and endometrial cells. It acts as a modulator of vasomotor tone, cell proliferation, and hormone production. (N Eng J Med 1995;333(6):356-63)

**Tree numbers:** - D12.644.276.400.225 - D12.776.467.400.225 - D23.529.400.225

**Synonyms:** - Endothelin Type 1