12-Hydroxy-5,8,10,14-eicosatetraenoic Acid

**Definition:** A lipoxygenase metabolite of ARACHIDONIC ACID. It is a highly selective ligand used to label mu-opioid receptors in both membranes and tissue sections. The 12-S-HETE analog has been reported to augment tumor cell metastatic potential through activation of protein kinase C. (J Pharmacol Exp Ther 1995; 274(3):1545-51; J Natl Cancer Inst 1994; 86(15):1145-51)

**Tree numbers:** - D10.251.355.255.100.300.425 - D10.251.355.310.166.550.425

**Synonyms:** - 12-HETE