Loss of Heterozygosity

**Definition:** The loss of one allele at a specific locus, caused by a deletion mutation; or loss of a chromosome from a chromosome pair, resulting in abnormal HEMIZYGOSITY. It is detected when heterozygous markers for a locus appear monomorphic because one of the ALLELES was deleted.

**Tree numbers:** - G05.365.590.029.530

**Synonyms:** - Allelic Loss - Heterozygosity, Loss of