Kininogen, High-Molecular-Weight

**Definition:** A plasma protein, molecular weight of 110 kD, that normally exists in plasma in a 1:1 complex with PREKALLIKREIN. HMWK is split by plasma kallikrein to produce BRADYKININ. The complex is a cofactor in the activation of coagulation factor XII. The product of this reaction, XIIa, in turn activates prekallikrein to KALLIKREINS. (From Stedman, 26th ed)

**Tree numbers:** - D12.644.276.812.654.350 - D12.776.124.125.635.480 - D12.776.467.812.654.350 - D12.776.811.420.350 - D23.119.630.480 - D23.469.050.375.425.350 - D23.529.812.654.350

**Synonyms:** - High-Molecular-Weight Kininogen - HMWK - Fitzgerald Factor - High Molecular Weight Kininogens - Kininogens, High Molecular Weight - High-Molecular-Weight Kininogens - High Molecular Weight Kininogen