Calcineurin

**Definition:** A CALCIUM and CALMODULIN-dependent serine/threonine protein phosphatase that is composed of the calcineurin A catalytic subunit and the calcineurin B regulatory subunit. Calcineurin has been shown to dephosphorylate a number of phosphoproteins including HISTONES; MYOSIN LIGHT CHAIN; and the regulatory subunits of CAMP-DEPENDENT PROTEIN KINASES. It is involved in the regulation of signal transduction and is the target of an important class of immunophilin-immunosuppressive drug complexes.

**Tree numbers:** - D08.811.277.352.650.625.150 - D12.644.360.087 - D12.776.476.559.150

**Synonyms:** - Protein Phosphatase-2B - Protein Phosphatase 3