Tissue Inhibitor of Metalloproteinases

**Definition:** A family of secreted protease inhibitory proteins that regulates the activity of SECRETED MATRIX METALLOENDOPEPTIDASES. They play an important role in modulating the proteolysis of EXTRACELLULAR MATRIX, most notably during tissue remodeling and inflammatory processes.

**Tree numbers:** - D12.776.815.875

**Synonyms:** - Tissue Inhibitor of Metalloproteinase - TIMP Proteins