Ryanodine Receptor Calcium Release Channel

**Definition:** A tetrameric calcium release channel in the SARCOPLASMIC RETICULUM membrane of SMOOTH MUSCLE CELLS, acting oppositely to SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES. It is important in skeletal and cardiac excitation-contraction coupling and studied by using RYANODINE. Abnormalities are implicated in CARDIAC ARRHYTHMIAS and MUSCULAR DISEASES.

**Tree numbers:** - D12.776.157.530.400.150.800 - D12.776.210.500.800 - D12.776.543.550.450.150.800 - D12.776.543.585.400.150.800

**Synonyms:** - Calcium-Ryanodine Receptor Complex - Receptor, Ryanodine - Ryanodine Receptor - Ca Release Channel-Ryanodine Receptor