Trans-Splicing

**Definition:** The joining of RNA from two different genes. One type of trans-splicing is the spliced leader type (primarily found in protozoans such as trypanosomes and in lower invertebrates such as nematodes) which results in the addition of a capped, noncoding, spliced leader sequence to the 5' end of mRNAs. Another type of trans-splicing is the discontinuous group II introns type (found in plant/algal chloroplasts and plant mitochondria) which results in the joining of two independently transcribed coding sequences. Both are mechanistically similar to conventional nuclear pre-mRNA cis-splicing. Mammalian cells are also capable of trans-splicing.

**Tree numbers:** - G02.111.760.700.750 - G03.839.700.750 - G05.308.700.700.750

**Synonyms:** - RNA Trans-Splicing - Trans RNA Splicing - Trans Splicing