N-Acetylgalactosamine-4-Sulfatase

**Definition:** An arylsulfatase that catalyzes the hydrolysis of the 4-sulfate groups of the N-acetyl-D-galactosamine 4-sulfate units of chondroitin sulfate and dermatan sulfate. A deficiency of this enzyme is responsible for the inherited lysosomal disease, Maroteaux-Lamy syndrome (MUCOPOLYSACCHARIDOSIS VI). EC 3.1.6.12.

**Tree numbers:** - D08.811.277.352.827.070.060 - D08.811.277.352.827.180.175.060

**Synonyms:** - Arylsulfatase B - N-Acetylgalactosamine 4-Sulfatase - N-Acetylgalactosamine-4-sulfate Sulfatase - N-Acetylgalactosamine-4-sulphate Sulphatase