D020104Level 7

Immunophilins

**Definition:** Members of a family of highly conserved proteins which are all cis-trans peptidyl-prolyl isomerases (PEPTIDYLPROLYL ISOMERASE). They bind the immunosuppressant drugs CYCLOSPORINE; TACROLIMUS and SIROLIMUS. They possess rotamase activity, which is inhibited by the immunosuppressant drugs that bind to them.

**Tree numbers:** - D08.811.399.325.500.400 - D12.776.543.750.705.400 - D12.776.827.344

**Synonyms:** - Immunophilin

GET/api/v1/systems/mesh/nodes/D020104

Official DownloadPublic Domain (US Government)Source

Hierarchy Explorer

Hierarchy ExplorerChevron to expand - click title to open

D021983Cyclophilins

D022021Tacrolimus Binding Proteins

Cross-system equivalences0

No cross-system equivalences mapped for this node.

Report a data issue