In Situ Nick-End Labeling

**Definition:** An in situ method for detecting areas of DNA which are nicked during APOPTOSIS. Terminal deoxynucleotidyl transferase is used to add labeled dUTP, in a template-independent manner, to the 3 prime OH ends of either single- or double-stranded DNA. The terminal deoxynucleotidyl transferase nick end labeling, or TUNEL, assay labels apoptosis on a single-cell level, making it more sensitive than agarose gel electrophoresis for analysis of DNA FRAGMENTATION.

**Tree numbers:** - E05.393.475

**Synonyms:** - In Situ Nick End Labeling - In Situ Nick End Labelling - In Situ Nick End-Labeling - In Situ Nick End-Labelling - In Situ Nick-End Labelling - Nick End-Labeling, In Situ - Nick End-Labelling, In Situ - Nick-End Labeling, In Situ - Nick-End Labelling, In Situ - TUNEL