Paraneoplastic Cerebellar Degeneration

**Definition:** Cerebellar degeneration associated with a remote neoplasm. Clinical manifestations include progressive limb and GAIT ATAXIA; DYSARTHRIA; and NYSTAGMUS, PATHOLOGIC. The histologic type of the associated neoplasm is usually carcinoma or lymphoma. Pathologically the cerebellar cortex and subcortical nuclei demonstrate diffuse degenerative changes. Anti-Purkinje cell antibodies (anti-Yo) are found in the serum of approximately 50% of affected individuals. (Adams et al., Principles of Neurology, 6th ed, p686)

**Tree numbers:** - C04.588.614.550.650 - C04.730.856.650 - C10.228.140.252.620 - C10.574.781.700

**Synonyms:** - Cerebellar Degeneration, Paraneoplastic - Cerebellar Syndrome, Paraneoplastic - Paraneoplastic Cerebellar Syndrome