Myopathy, Central Core

**Definition:** An inherited congenital myopathic condition characterized by weakness and hypotonia in infancy and delayed motor development. Muscle biopsy reveals a condensation of myofibrils and myofibrillar material in the central portion of each muscle fiber. (Adams et al., Principles of Neurology, 6th ed, p1452)

**Tree numbers:** - C05.651.575.300 - C10.668.491.550.300

**Synonyms:** - Central Core Disease - Central Core Disease of Muscle - Central Core Myopathy - Shy-Magee Syndrome