Lymphoma, Mantle-Cell

**Definition:** A form of non-Hodgkin lymphoma having a usually diffuse pattern with both small and medium lymphocytes and small cleaved cells. It accounts for about 5% of adult non-Hodgkin lymphomas in the United States and Europe. The majority of mantle-cell lymphomas are associated with a t(11;14) translocation resulting in overexpression of the CYCLIN D1 gene (GENES, BCL-1).

**Tree numbers:** - C04.557.386.480.525 - C15.604.515.569.480.525 - C20.683.515.761.480.525

**Synonyms:** - Lymphoma, Lymphocytic, Diffuse, Poorly-Differentiated - Lymphoma, Small-Cell, Centrocytic - Mantle-Cell Lymphoma - Mantle-Zone Lymphoma - Diffuse Lymphocytic Lymphoma, Poorly-Differentiated - Lymphocytic Lymphoma, Diffuse, Poorly Differentiated - Lymphocytic Lymphoma, Diffuse, Poorly-Differentiated - Lymphoma, Lymphocytic, Diffuse, Intermediate Differentiated - Lymphoma, Centrocytic Small-Cell