Proto-Oncogene Proteins c-rel

**Definition:** Cellular DNA-binding proteins encoded by the rel gene (GENES, REL). They are expressed predominately in hematopoietic cells and may play a role in lymphocyte differentiation. Rel frequently combines with other related proteins (NF-KAPPA B, I-kappa B, relA) to form heterodimers that regulate transcription. Rearrangement or overexpression of c-rel can cause tumorigenesis.

**Tree numbers:** - D12.776.260.682 - D12.776.624.664.700.192 - D12.776.660.767 - D12.776.930.730

**Synonyms:** - p68 c-rel - Proto-Oncogene Protein c-rel - rel Proto-Oncogene Proteins - c-rel Protein - p68(c-rel) - rel Proto-Oncogene Product p68 - Proto-Oncogene Products c-rel - c-rel Proteins - Proto-Oncogene Proteins rel