RGS Proteins

**Definition:** A large family of evolutionarily conserved proteins that function as negative regulators of HETEROTRIMERIC GTP-BINDING PROTEINS. RGS PROTEINS act by increasing the GTPase activity of the G alpha subunit of a heterotrimeric GTP-binding protein, causing it to revert to its inactive (GDP-bound) form.

**Tree numbers:** - D12.644.360.325.150.750 - D12.776.476.325.150.750

**Synonyms:** - RGS Protein (G-Protein Signaling) - Regulators of G-Protein Signaling Proteins