D020714Level 4

Maximum Tolerated Dose

**Definition:** The highest dose of a biologically active agent given during a chronic study that will not reduce longevity from effects other than carcinogenicity. (from Lewis Dictionary of Toxicology, 1st ed)

**Tree numbers:** - E05.940.481 - G07.690.936.625

**Synonyms:** - Maximal Tolerated Dose - Maximally Tolerated Dose

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