Receptor, trkA

**Definition:** A protein-tyrosine kinase receptor that is specific for NERVE GROWTH FACTOR; NEUROTROPHIN 3; neurotrophin 4, neurotrophin 5. It plays a crucial role in pain sensation and thermoregulation in humans. Gene mutations that cause loss of receptor function are associated with CONGENITAL INSENSITIVITY TO PAIN WITH ANHIDROSIS, while gene rearrangements that activate the protein-tyrosine kinase function are associated with tumorigenesis.

**Tree numbers:** - D08.811.913.696.620.682.725.400.660 - D12.776.476.568.400.660 - D12.776.543.750.630.496 - D12.776.543.750.750.400.550.550

**Synonyms:** - Proto-Oncogene Products c-trk - Proto-Oncogene Protein trk - gp140(c-TRK) - trk Proto-Oncogene Protein - NTRK1 Receptor - Receptor, Neurotrophic Tyrosine Kinase Type 1 - c-trk Protein - gp140 c-trk - p140-trkA - trk1 Transforming Tryrosine Kinase - Neurotrophic Tyrosine Kinase Receptor Type 1 - trkA Receptor