MAP Kinase Kinase Kinases

**Definition:** Mitogen-activated protein kinase kinase kinases (MAPKKKs) are serine-threonine protein kinases that initiate protein kinase signaling cascades. They phosphorylate MITOGEN-ACTIVATED PROTEIN KINASE KINASES; (MAPKKs) which in turn phosphorylate MITOGEN-ACTIVATED PROTEIN KINASES; (MAPKs).

**Tree numbers:** - D08.811.913.696.620.682.700.559 - D12.776.476.563.554

**Synonyms:** - MAP3 Kinase - MAPKKK - Mitogen-Activated Protein Kinase Kinase Kinase - MAP Kinase Kinase Kinase - MAPKKKs - Kinases, MAP Kinase Kinase - MAP3 Kinases - Mitogen-Activated Protein Kinase Kinase Kinases