Self-Sustained Sequence Replication

**Definition:** An isothermal in-vitro nucleotide amplification process. The process involves the concomitant action of a RNA-DIRECTED DNA POLYMERASE, a ribonuclease (RIBONUCLEASES), and DNA-DIRECTED RNA POLYMERASES to synthesize large quantities of sequence-specific RNA and DNA molecules.

**Tree numbers:** - E05.393.620.700

**Synonyms:** - Nucleic Acid Sequence-Based Amplification