BRCA2 Protein

**Definition:** A large, nuclear protein, encoded by the BRCA2 gene (GENE, BRCA2). Mutations in this gene predispose humans to breast and ovarian cancer. The BRCA2 protein is an essential component of DNA repair pathways, suppressing the formation of gross chromosomal rearrangements. (from Genes Dev. 2000;14(11):1400-6)

**Tree numbers:** - D12.776.313.249 - D12.776.624.776.101 - D12.776.660.105

**Synonyms:** - FANCD1 Protein - Fanconi Anemia Complementation Group D1 Protein - BRCA2 Gene Product - Breast Cancer 2 Gene Product - Fanconi Anemia Group D1 Complementing Protein - Breast Cancer 2 Protein - Fanconi Anemia Group D1 Protein