E-Box Elements

**Definition:** DNA locations with the consensus sequence CANNTG. ENHANCER ELEMENTS may contain multiple copies of this element. E-boxes play a regulatory role in the control of transcription. They bind with basic helix-loop-helix (bHLH) type TRANSCRIPTION FACTORS. Binding specificity is determined by the specific bHLH heterodimer or homodimer combination and by the specific nucleotides at the 3rd and 4th position of the E-box sequence.

**Tree numbers:** - G02.111.570.080.689.330.240 - G05.360.080.689.330.240 - G05.360.340.024.340.137.750.249.240

**Synonyms:** - E-Box Motifs - E-Box Sequences - E-Box Sites