Phosphofructokinase-2

**Definition:** An allosteric enzyme that regulates glycolysis and gluconeogenesis by catalyzing the transfer of a phosphate group from ATP to fructose-6-phosphate to yield fructose-2,6-bisphosphate, an allosteric effector for the other 6-phosphofructokinase, PHOSPHOFRUCTOKINASE-1. Phosphofructokinase-2 is bifunctional: the dephosphorylated form is a kinase and the phosphorylated form is a phosphatase that breaks down fructose-2,6-bisphosphate to yield fructose-6-phosphate.

**Tree numbers:** - D08.811.277.352.650.622 - D08.811.641.843 - D08.811.913.696.620.225.850.750

**Synonyms:** - 6PF2K - 6-Phosphofructo-2-kinase - Fru-6-P,2-kinase - Fructose-6-P,2-kinase - Fructose-6-phosphate,2-kinase - ATP-D-Fructose-6-phosphate 2-phosphotransferase