Hydroxymethylglutaryl-CoA Reductases, NAD-Dependent

**Definition:** Specific hydroxymethylglutaryl CoA reductases that utilize the cofactor NAD. This class of enzymes performs a catabolic role in microorganisms such as Pseudomonas mevalonii where it oxidatively acetylates MEVALONIC ACID to form 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A and NADH.

**Tree numbers:** - D08.811.682.047.820.150.415.250

**Synonyms:** - HMG CoA Reductase, NAD-Dependent - HMG CoA Reductases, NAD-Dependent - Hydroxymethylglutaryl CoA Reductase, NAD-Dependent - 3-Hydroxy-3-methylglutaryl CoA-Reductase, NAD-Dependent