RNA Interference

**Definition:** A gene silencing phenomenon whereby specific dsRNAs (RNA, DOUBLE-STRANDED) trigger the degradation of homologous mRNA (RNA, MESSENGER). The specific dsRNAs are processed into SMALL INTERFERING RNA (siRNA) which serves as a guide for cleavage of the homologous mRNA in the RNA-INDUCED SILENCING COMPLEX. DNA METHYLATION may also be triggered during this process.

**Tree numbers:** - G05.308.203.374.790

**Synonyms:** - RNAi - Posttranscriptional Gene Silencing - RNA Silencing - Post-Transcriptional Gene Silencing - Gene Silencing, Post-Transcriptional