RNA-Binding Protein FUS

**Definition:** A multifunctional heterogeneous-nuclear ribonucleoprotein that may play a role in homologous DNA pairing and recombination. The N-terminal portion of protein is a potent transcriptional activator, while the C terminus is required for RNA binding. The name FUS refers to the fact that genetic recombination events result in fusion oncogene proteins (ONCOGENE PROTEINS, FUSION) that contain the N-terminal region of this protein. These fusion proteins have been found in myxoid liposarcoma (LIPOSARCOMA, MYXOID) and acute myeloid leukemia.

**Tree numbers:** - D12.776.157.725.500.313.905 - D12.776.157.725.813.750.905 - D12.776.624.664.700.915 - D12.776.664.962.500.313.902 - D12.776.664.962.813.750.902

**Synonyms:** - TLS Protein - hnRNP P2 - Translocated in Liposarcoma Protein - FUS RNA-Binding Protein - Fusion Protein in Myxoid Liposarcoma - FUS Protein - POMp75 Protein