Iron Regulatory Protein 1

**Definition:** A multifunctional iron-sulfur protein that is both an iron regulatory protein and cytoplasmic form of aconitate hydratase. It binds to iron regulatory elements found on mRNAs involved in iron metabolism and regulates their translation. Its RNA binding ability and its aconitate hydrolase activity are dependent upon availability of IRON.

**Tree numbers:** - D08.811.520.241.300.050.500 - D12.776.157.427.374.375.960 - D12.776.157.725.374 - D12.776.494.500 - D12.776.556.579.374.375.960 - D12.776.664.962.374

**Synonyms:** - IRP-1 Protein - IRP1 Protein - IRE-BP1 - Aconitase 1, Soluble - ACO1 Protein - Ferritin Repressor Protein