ADP-ribosyl Cyclase

**Definition:** A membrane-bound or cytosolic enzyme that catalyzes the synthesis of CYCLIC ADP-RIBOSE (cADPR) from nicotinamide adenine dinucleotide (NAD). This enzyme generally catalyzes the hydrolysis of cADPR to ADP-RIBOSE, as well, and sometimes the synthesis of cyclic ADP-ribose 2' phosphate (2'-P-cADPR) from NADP.

**Tree numbers:** - D08.811.277.450.430.400.060 - D08.811.913.400.725.115.660.060

**Synonyms:** - ADP Ribose Cyclase - ADPR Cyclase - Adenosine Diphosphate Ribose Cyclase